Thirteen-year-old female twins presented one week apart with documented Mycoplasma pneumoniae respiratory infection.Each developed venous thrombosis and pulmonary emboli in association venus tops and blouses with transient self-limited para-infectious anti-phospholipid antibodies.Comprehensive evaluation revealed no identifiable genetic prothrombotic variables.Both children recovered after receiving antibiotics and anticoagulation therapy.Thrombotic complications associated with Mycoplasma pneumoniae infections are rare, particularly in children; the occurrence of this complication in identical 30x24x24 wall cabinet twins has not been previously reported.